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Estrogen HRT methods (oral, patch, injections) offered by FOLX Health
Estrogen HRT methods (oral, patch, injections) offered by FOLX Health

Estrogen Hormone Replacement Therapy (HRT) Methods and Dosage Offered by FOLX

Written By

FOLX Health

Jan 26, 2022

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Are you someone who is interested in starting estrogen hormone replacement therapy (HRT) for the first time or are looking to try a different method or dosage? FOLX has different options to choose from: the oral/sublingual estrogen pill, estrogen injection, and transdermal estrogen patch. Note that estrogen is absorbed into the body differently depending on which method you choose, and you can learn more about them all below.

With each method of estrogen HRT, there are different dosage levels that can result in slower or quicker physical changes. Whatever method and dosage you decide is right for you will depend on your health history and personal goals. Remember, the dose and routes for estrogen gender-affirming hormone therapy you choose is always in your control. FOLX offers hormones for transgender people, trans women, trans feminine, non-binary and other gender variant people looking to start or continue estrogen hormone replacement therapy. 

Don’t worry if you’re unsure about which route or dosage is the perfect combination for you; fortunately, the way you take estrogen can be changed along the way and no one combination is fixed. Our clinicians will work with you to figure out what method is best for you at any point during your gender journey. Read on to learn more information about FOLX’s offerings for estrogen hormone replacement therapy.

Oral/sublingual estradiol pill

Oral estrogen tablet

The estradiol pill is a dose of estrogen taken daily, once or multiple times a day. These pills are usually dissolved under the tongue and can take up to 30 minutes to dissolve.

Common pros and cons of oral / sublingual estrogen

While a pill can be more appealing than a needle for those who struggle with self-injection, there are both pros and cons to the oral/sublingual method just like other routes. Whether this method is right for you will be entirely dependent on your own preferences. 

Oral estrogen pro and cons

Oral / sublingual estrogen dosage levels

Transgender women may prefer to jumpstart their estrogen HRT journey with an average dose while other trans feminine and/or non-binary people may prefer to microdose, or receive a lower dose of estrogen. There are no fixed dosages for specific gender identities, so we encourage that you choose whatever the optimal dosage is for your goals.

Estrogen injections


Self-administered estrogen injection shots occur weekly or biweekly (every other week). There are two injection types: intramuscular (IM), which is injected into the muscle, and subcutaneous (Sub-Q), which is injected into the fatty tissue under the skin.

There are two different types of injectable estrogen: estradiol valerate and estradiol cypionate. The most common injectable estrogen used in the United States is estradiol valerate, which FOLX usually initiates for those pursuing the injectable estrogen HRT route. Both valerate and cypionate are prodrugs of estradiol and have similar affinity for estrogen receptors in the body, meaning they're equally as effective.

What are the major differences? Valerate is suspended in castor oil while cypionate is suspended in cottonseed oil. Valerate has a more predictable pattern of movement throughout the body (aka pharmacokinetics). Meanwhile, cypionate has a longer active life, which means it can be dosed every two weeks. However, cypionate is often only prescribed if valerate is unavailable. It’s important to know that dosing varies for each. if switching from one to the other, dosage would also shift substantially.

If you experience needle phobia and injection anxiety, check out our tips to overcoming self-injection fear!

Common pros and cons of injectable estrogen

While self-injecting may be scary for some, the advantages might outweigh the disadvantages depending on what you want for your journey.  

Injectable estrogen pro and cons

Injectable estrogen dosage levels

How do you know which injectable estrogen dosage is right for you? Check out the chart below for variations of dosage between estradiol valerate and estradiol cypionate.


Estrogen transdermal patch

FOLX estrogen patches

The transdermal estrogen patch enables estrogen to be absorbed through the skin and into the bloodstream. A patch is applied to skin every three to four days. While the patch is prone to falling off with exposure to moisture, it can also be covered up with plastic to avoid falling off.

Common pros and cons of estrogen transdermal patch 

If you think the estrogen patch is the most attractive estrogen replacement therapy option for you, take a moment to read about the pros and cons.

Estrogen patch pros and cons

Transdermal patch estrogen dosage levels

While all estrogen transdermal patches are to be replaced every three to four days, dosages vary depending on your desired transition goals.

Anti-androgens and/or progesterone

Estrogen HRT can also include taking supplemental medications known as anti-androgens and/or progesterone in addition to one of the above methods. While not everyone on estrogen HRT pursues either, you may consider either or both.

Androgens are described as hormones that regulate the development of sex characteristics, such as testosterone. Moreover, anti-androgens work to block the effects of androgens, including testosterone. FOLX offers spironolactone as well as finasteride and dutasteride. 

Progesterone is another type of hormone that can help improve breast or areolar development in those who don’t achieve full breast development with estrogen alone. However, medical research on progesterone is limited and has been unfortunately inconclusive.

For more information about supplemental medications for estrogen HRT and what FOLX offers, check out this guide.

With the multiple routes and dosages of estrogen replacement therapy, there are several ways to find the one that fits best for you. For those ready to get started with FOLX for estrogen HRT, the process begins
here. For existing FOLX members with questions about dosage, don't hesitate to schedule time with a clinician. Have more questions or concerns? Read up on estrogen here and feel free to contact us directly at

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